Weber's acting career has included many featured roles in music videos, most notably in Daize Shayne's Naughty Girl. Weber's television roles include appearances with Bon Jovi in Las Vegas, Kid Rock in CSI: NY, Jenny McCarthy in Party at the Palms and Denise Richards in Sex, Love & Secrets. Other popular shows she has appeared in include The Tonight Show, Bones, Threshold, Everybody Hates Chris, Two and a Half Men and many programs new to 2007 Cavemen, Big Shots, Life and Disneys Wizards of Waverly Place. Holly has filmed several Motion pictures including Ron Howard's Frost/Nixon, Adam Sandler's You Don't Mess with the Zohan and Click as well as being featured in Supergator and Room Service.